significant roles played by interleukin-10 in outcome of pregnancy

imbalanced immune responses against fetus alloantigens can lead to abnormality in pregnancy. interleukin-10(il-10) plays key roles in regulation of immune responses against self and foreign antigens to induce tolerance to these antigens. therefore, alteration in expression of il-10 during pregnancy may result in several pathologic conditions such as preterm labor. il-10 leads to a normal pregnancy via several molecular mechanisms including development of tolerogenic dendritic cells, t regulatory lymphocytes and activation of the jak1/stat3 pathway in the target cells. this review has collected recent data regarding the status of il-10 expression during term and preterm deliveries and also its molecular mechanisms that lead to a normal pregnancy.